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KMID : 1188320130070030357
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Gut and Liver
2013 Volume.7 No. 3 p.357 ~ p.362
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N-Acetylcysteine Improves Pancreatic Microcirculation and Alleviates the Severity of Acute Necrotizing Pancreatitis
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Bing-Qing Du
Yue-Ming Yang
Yong-Hua Chen
Xu-Bao Liu
Gang Mai
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Abstract
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Background/Aims:To investigate the beneficial effect of N-Acetylcysteine (NAC) on pancreatic microvascular perfusion in acute necrotizing pancreatitis (ANP).
Methods:Fifty-four rats were divided into a control group, an ANP group and an NAC-treated group. The ANP model was established by a retrograde injection of 3% sodium taurocholate into the pancreatic duct. The NAC-treated group received an intravenous infusion of NAC just 2 hours before and 30 minutes after the induction of ANP. The pancreatic microvascular perfusion was measured with laser Doppler flowmetry and pancreatic samples were collected for histological examination.
Results:The microvascular perfusion in the NAC-treated group decreased slightly and exhibited a significant increase compared to the ANP group (p<0.01). A pathological examination revealed that edema and inflammatory infiltration decreased, and the hemorrhaging and necrosis of the pancreas were significantly reduced.
Conclusions:NAC could improve pancreatic microvascular perfusion and alleviate the severity of sodium taurocholate-induced ANP, possibly representing a new therapeutic approach to prevent the progression of ANP.
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KEYWORD
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Acetylcysteine, Acute necrotizing pancreatitis, Pancreatic microvascular perfusion, Laser-Doppler flowmetry, Taurocholic acid
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